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Pregnancy and older age both call for a careful weighing of risk against benefit before treatment starts. It passes both the placenta and into breast milk, so neonatal floppiness and withdrawal are recognised risks. Owing to the fact that clearance declines with age, starting doses in older patients are reduced notably to guard against toxicity.
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Gastrointestinal absorption is usually swift and complete, with peak plasma concentrations achieved within 1 to 2 hours for immediate-release tablets, and up to 9 hours for extended-release formulations. The presence of food in the gastric tract can delay the time to peak concentration (Tmax) but does not notably alter the overall extent of absorption (AUC), allowing for flexible administration concerning meals.
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Up-to-date studies put generics through strict bioequivalence testing measured against the branded product. The active component is the same in each case; it is the binders and fillers used in production that can modestly change dissolution. Patients who notice the difference between formulations should as such be dispensed the same one dependably.
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Clinical Summary
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